General Information

  • ID:  hor006558
  • Uniprot ID:  P61365(82-131)
  • Protein name:  Osteocrin
  • Gene name:  Ostn
  • Organism:  Rattus norvegicus (Rat)
  • Family:  Osteocrin family
  • Source:  animal
  • Expression:  Is down-regulated by 1,25-dihydroxy vitamin D3. |Expression was highest in embryos and neonates, peaking at 4 days of age in both calvaria and long bones and decreasing steadily with age to very low levels in 8-month-old long bones. The age-related decrea
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea , Myomorpha (suborder), Rodentia (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005102 signaling receptor binding; GO:0005179 hormone activity
  • GO BP:  GO:0001503 ossification; GO:0003416 endochondral bone growth; GO:0007166 cell surface receptor signaling pathway; GO:0009755 hormone-mediated signaling pathway; GO:0030154 cell differentiation; GO:0045668 negative regulation of osteoblast differentiation; GO:0046325 negative regulation of glucose import; GO:1903860 negative regulation of dendrite extension
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  SFSGFGSPLDRLSAGSVEHRGKQRRVVDHSKKRFGIPMDRIGRNRLSSSR
  • Length:  50(82-131)
  • Propeptide:  MLDWRLASAHFLLAMILMLWGSGKAFSVDLASEASEFGAESLQSPPTTREEKSATELAAKLLLLDDLVSLENDVFETKKKRSFSGFGSPLDRLSAGSVEHRGKQRRVVDHSKKRFGIPMDRIGRNRLSSSRG
  • Signal peptide:  MLDWRLASAHFLLAMILMLWGSGKA
  • Modification:  T50 Arginine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, t
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Npr3
  • Target Unid:  P70180
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P61365-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006558_AF2.pdbhor006558_ESM.pdb

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Physical Information

Mass: 650050 Formula: C239H396N86O70S
Absent amino acids: CTWY Common amino acids: RS
pI: 12.42 Basic residues: 14
Polar residues: 16 Hydrophobic residues: 12
Hydrophobicity: -94.6 Boman Index: -18054
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 58.4
Instability Index: 4061.6 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  14523025
  • Title:  Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype.
  • PubMed ID:  15044443
  • Title:  Musclin, a novel skeletal muscle-derived secretory factor.
  • PubMed ID:  17951249
  • Title:  Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth